LEV65

Can a GAGome score identify which firefighters will develop cancer in the next five years?

Firefighters are occupationally exposed to carcinogens, and the IARC classifies firefighting as carcinogenic to humans. Cancer incidence and mortality are elevated across several cancer types, yet most of those cancers have no established screening programme.

Design: Retrospective observational cohort study in actively working firefighters, using plasma and urine collected in the VCC-MCEDFF-001 study at Vincere Cancer Center, Scottsdale, Arizona. Cancer diagnoses are recorded over five years of annual registry follow-up. The primary endpoint is incident any-type cancer; a secondary endpoint compares performance against the PLCOm2014 risk model. Target enrolment ≥2,000.

Status: The trial is in the post-enrollment follow-up period. Primary analysis is pending completion of follow-up and database lock. GAGome results are for research purposes and are not returned to participants.

In collaboration with Vincere Cancer Center.

VCC-MCEDFF-001 is registered at ClinicalTrials.gov (NCT05780957).